Pharmacokinetics of anidulafungin during albumin dialysis

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Pharmacokinetics of anidulafungin during albumin dialysis

In the ICU setting, current guidelines recommend echinocandins as the first-line treatment for invasive candidiasis [1]. Albumin dialysis (AD) has been used in the ICU as supportive therapy for hepatic failure, but this technique can significantly enhance drug elimination [2]. We prescribed anidulafungin for suspected invasive candidiasis in a patient with severe liver failure treated with AD a...

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Pharmacokinetics and Pharmacodynamics of Anidulafungin

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Multiple-dose pharmacokinetics of anidulafungin during continuous venovenous haemofiltration.

BACKGROUND Clinical studies support a role for anidulafungin as first-line treatment of invasive candidiasis in critically ill patients and postulate no need for dose adjustments in mild to severe renal failure. Although intensive care patients requiring renal replacement therapy are at particular risk of invasive fungal infection, no pharmacokinetic data on anidulafungin during continuous veno...

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Pharmacokinetics of anidulafungin during venovenous extracorporeal membrane oxygenation

Echinocandins are currently considered the first-line treatment for invasive candidiasis (IC) in the intensive care unit (ICU) [1, 2]. However, extracorporeal membrane oxygenation (ECMO), a rescue therapy used in patients with severe acute respiratory distress syndrome (ARDS) [3], could alter the pharmacokinetics of certain drugs [4]. We prescribed anidulafungin for suspected IC in a patient wi...

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ژورنال

عنوان ژورنال: Critical Care

سال: 2014

ISSN: 1364-8535

DOI: 10.1186/cc13805